Injection
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Starting at $159/mo
Fertility supportTesticular stimulation
Enclomiphene Capsules
RxPrescription onlyTaken by mouth · Once a day · 12.5–75 mg · Fertility support · Testicular stimulation
Starting at $119/mo
Enclomiphene (active isomer of clomiphene): pure active form, faster-acting, shorter half-life; stimulates LH and testosterone production while preserving fertility. Dosed more frequently but clears faster.
How many capsules per month?
MonthlyEvery 3 months
30 capsulesper month
You'll receive 30 capsules per month. $139 billed monthly. Cancel anytime.
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Faster-acting than racemic clomiphene; shorter half-life means cleaner peaks
- Pure active isomer, more potent per mg
- Maintains fertility and testicular function; clears quickly
Every plan includes
- Personalized, physician-guided plan
- 30 capsules per month, monthly and 3-month
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is enclomiphene?
(en-KLO-mi-feen)
Enclomiphene is the active isomer of clomiphene, meaning it contains only the form that binds to estrogen receptors and stimulates LH. Racemic clomiphene (regular clomiphene) contains both active and inactive isomers; enclomiphene is pure active form. It is faster-acting, peaks higher, and clears in 24 hours rather than days. Typical dose: 12.5–25 mg daily or every other day. Used off-label like clomiphene for fertility preservation.
- How it is taken
- Taken by mouth
- How often
- Once a day
- Dose range
- 12.5–75 mg
- Form
- Fertility support · Testicular stimulation
Pure active isomer
faster LH rise, cleaner pharmacokinetics
Enclomiphene has a much shorter half-life than racemic clomiphene (24 hours vs. 30+ hours), producing faster LH spikes and clearer on/off kinetics. Some men report faster recovery of natural testosterone on enclomiphene than on regular clomiphene.
How it works,
week by week.
Day 1
US-licensed physician reviews your fertility goals, testicular health, and plans on testosterone therapy. Discussion of clomiphene vs. enclomiphene vs. hCG or combination.
Week 1
Start clomiphene 25–50 mg daily or hCG 500–2,500 IU once weekly, depending on your plan. Baseline semen analysis or testicular ultrasound may be ordered to track changes.
Weeks 4–8
LH and testosterone levels rise as clomiphene/hCG stimulates the testicles. Testicular function is preserved. Sperm production remains normal or improves.
Month 2–3
Follow-up labs (LH, FSH, testosterone, sperm count). Dose adjusted if needed. If combining hCG with testosterone therapy, check testosterone levels.
Beyond
Continue fertility support as long as you take testosterone therapy. If you stop testosterone, fertility usually returns within 3–6 months with continued clomiphene/hCG support.
What you may notice,
and when.
Testicles stay healthy
size and function maintained on testosterone therapy
Sperm production continues
fertility potential preserved even during testosterone use
Faster recovery if you stop
endogenous testosterone and sperm return quickly when therapy ends
Lab monitoring required
LH, FSH, sperm count tracked to ensure response
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Clomiphene, enclomiphene, and hCG are prescribed off-label to preserve fertility and testicular function during testosterone therapy. Common side effects: mild headache, mood changes, abdominal discomfort. Clomiphene and enclomiphene may cause visual changes (blurred vision, floaters) in ~1% of users, report immediately if vision changes occur. hCG carries a small risk of ovarian hyperstimulation-like syndrome in some men if doses are very high. Tell your physician about prior fertility issues, current fertility plans, or any family history of gynecomastia or testicular disease. Stop and seek care for severe vision changes, severe headache, or testicular pain.
The research behind
enclomiphene.
Enclomiphene is a clomiphene isomer that raises the body's own testosterone by signalling the pituitary. Human evidence is small trials, and it is not FDA-approved.
- Testosterone and spermsperm kept
In a randomized trial in men with secondary hypogonadism, oral enclomiphene raised morning testosterone to levels similar to a 1% testosterone gel, while FSH and LH rose and sperm counts were kept. The trial was phase II, not phase 3.
Wiehle et al., Fertil Steril 2014 - Regulatory statusnot FDA-approved
We found no FDA approval of enclomiphene. Its compounding status is contested in secondary sources, so the FDA compounding guidance is the place to check the current position for a given pharmacy.
FDA, human drug compounding - Long-term outcomesno long-term trials
We found no published trial following enclomiphene users for years, or comparing it with clomiphene or testosterone on symptoms and outcomes.
Search of PubMed for enclomiphene trials
What the studies found
- Raises the body's own testosterone: morning testosterone rose to levels similar to a 1% testosterone gel (Wiehle et al., Fertil Steril 2014).
- Keeps sperm counts while raising testosterone (Wiehle et al., Fertil Steril 2014).
- Across clomiphene and enclomiphene trials, total testosterone rose by about 274 ng/dL against placebo, with high variation between studies (Hohl et al., Arch Endocrinol Metab 2025).
The trial result is with the studied enclomiphene citrate at its studied dose, averaged over men. Compounded enclomiphene was not studied in these trials, and purity and dose vary between pharmacies.
What this does not say
- Sperm preservation in the 2014 trial is a laboratory outcome, not a proven pregnancy rate.
- The 2014 trial is a single phase II study.
- The long-term safety of the drug is not established.
The research
behind it.
Enclomiphene is the (Z)-isomer of clomiphene, the form that binds strongly to estrogen receptors. Racemic clomiphene is 50% enclomiphene and 50% zuclomiphene (inactive). Enclomiphene's short half-life means it does not accumulate.
In off-label use for men seeking fertility preservation or faster recovery of natural testosterone, enclomiphene offers pharmacokinetic advantages over racemic clomiphene. Clinical data in men are emerging.
Testosterone beyond the gym:
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Enclomiphene Capsules?
Taken by mouth, once a day. The starting prescription is 1 capsule (12.5 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Enclomiphene Capsules come in?
The pharmacy carries 3: 12.5 mg, 51 mg, 75 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why use enclomiphene instead of regular clomiphene?
Enclomiphene is the pure active form and has a much shorter half-life (24 hours vs. 30+ days for racemic clomiphene). This means faster LH response, no drug accumulation, and quicker recovery if you stop. Some men report better sleep and mood on enclomiphene. If you have had issues with regular clomiphene, your physician may try enclomiphene.
Do I need clomiphene or hCG if I am on testosterone therapy?
Not always. If you are not concerned about fertility or testicular size, and your testosterone therapy is working well, neither is necessary. But if you want to preserve sperm production, prevent testicular atrophy, or plan a family in the future, your physician will recommend one.
Can I use clomiphene and hCG together?
Yes. Some physicians combine them for synergistic fertility preservation: clomiphene stimulates the pituitary (LH/FSH), hCG directly stimulates the testicles (testosterone/sperm). This combination is off-label but used clinically.
If I stop testosterone, will my fertility return?
Yes, usually within 3–6 months if you used clomiphene or hCG alongside testosterone. Without fertility support, recovery can take 6–12 months or longer. This is why fertility preservation on testosterone is important if you plan a family.
How often do I check sperm count or testicular health?
Initial baseline: before starting or at first visit. Then: every 3–6 months on clomiphene/hCG, or annually if on testosterone long-term. Semen analysis is the gold standard for sperm count; testicular ultrasound tracks size.
Enclomiphene educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
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9 capsules per month
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Capsule
Anastrozole Capsules
Anastrozole, an aromatase inhibitor used in men to control estrogen levels during testosterone therapy. Prescribed and dosed by a licensed physician.
9 capsules per month
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Tablet
Anastrozole Tablets
FDA-approved anastrozole tablets, an aromatase inhibitor used at low doses in men on testosterone therapy whose estradiol runs high. Prescribed by a licensed physician only after blood work.
5 tablets per month
Starting at $63/mo
References
- 1.Clomiphene citrate for men with testosterone deficiency: a review of pharmacology and outcomes. Fertil Steril, 2016
- 2.Human chorionic gonadotropin in testosterone replacement therapy for hypogonadal men: a review. J Androl, 2012
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.