Injection
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Starting at $159/mo
Men's healthFertilityTestosterone
Enclomiphene
RxPrescription onlyTaken by mouth · Once a day · 12.5–25 mg · Men's health · Fertility · Testosterone
Starting at $149/mo
An oral selective estrogen receptor modulator (SERM) that stimulates your body's own testosterone production and preserves fertility. Once-daily capsule for men who want testosterone support without suppressing sperm production.
How many capsules per month?
MonthlyEvery 3 months
30 capsulesper month
You'll receive 30 capsules per month. $199 billed monthly. Cancel anytime.
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Raises LH and FSH so your body makes its own testosterone
- Preserves sperm production and testicular size, unlike external testosterone
- Convenient oral capsule, once daily, no injections
Every plan includes
- Personalized, physician-guided plan
- 30 capsules per month, monthly and 3-month
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is enclomiphene?
(en-KLOM-i-feen)
Enclomiphene is the active form of clomiphene that binds to estrogen receptors in the brain, tricking the pituitary into increasing LH and FSH—the signals that tell your testes to make testosterone and sperm. Unlike testosterone replacement therapy, which shuts those signals down, enclomiphene keeps them alive. It is taken as a compounded oral capsule, typically 12.5 or 25 mg once daily.
- How it is taken
- Taken by mouth
- How often
- Once a day
- Dose range
- 12.5–25 mg
- Form
- Men's health · Fertility · Testosterone
LH + FSH
the two pituitary hormones enclomiphene raises to stimulate natural testosterone production
Enclomiphene is off-label in the US; it is a SERM with evidence in hypogonadism. Your physician decides if it fits your goals and health.
How it works,
week by week.
Day 1
A US-licensed physician reviews your testosterone levels, fertility goals, history and symptoms, and determines your starting dose (usually 12.5 or 25 mg daily).
Weeks 1–4
Take one capsule daily. Your pituitary begins increasing LH and FSH, signaling your testes to produce testosterone. Most men feel the effects within two to four weeks.
Month 2
A follow-up labs panel checks your testosterone, LH, FSH and estradiol. Your physician adjusts the dose if needed to keep levels steady and side effects minimal.
Month 3
Ongoing monitoring. Your semen parameters may be checked if fertility is your goal. Your physician confirms the dose and any adjustments.
Beyond
Enclomiphene runs as long as you need it. Your physician reviews labs and your response at least every 3–6 months.
What you may notice,
and when.
Testosterone rises
your own body makes it, not external replacement
Sperm counts improve
or stay intact, unlike on external testosterone
Testicular function preserved
size and production stay active
Energy and mood
as testosterone levels normalize
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Enclomiphene is generally well tolerated. The most common side effects are mild: headache, nausea, blurred vision or temporary vision changes (stop immediately and report to your physician), mood changes, and rarely, blood clots or deep vein thrombosis. Because it stimulates the pituitary, it is not prescribed with a pituitary adenoma. It can raise estradiol; your physician monitors this with labs. Seek care immediately for leg swelling, chest pain, shortness of breath, or sudden vision loss. Tell your physician about every medication, especially estrogen blockers or other hormone treatments.
The research behind
enclomiphene.
Enclomiphene is a clomiphene isomer that raises the body's own testosterone by signalling the pituitary. Human evidence is small trials, and it is not FDA-approved.
- Testosterone and spermsperm kept
In a randomized trial in men with secondary hypogonadism, oral enclomiphene raised morning testosterone to levels similar to a 1% testosterone gel, while FSH and LH rose and sperm counts were kept. The trial was phase II, not phase 3.
Wiehle et al., Fertil Steril 2014 - Regulatory statusnot FDA-approved
We found no FDA approval of enclomiphene. Its compounding status is contested in secondary sources, so the FDA compounding guidance is the place to check the current position for a given pharmacy.
FDA, human drug compounding - Long-term outcomesno long-term trials
We found no published trial following enclomiphene users for years, or comparing it with clomiphene or testosterone on symptoms and outcomes.
Search of PubMed for enclomiphene trials
What the studies found
- Raises the body's own testosterone: morning testosterone rose to levels similar to a 1% testosterone gel (Wiehle et al., Fertil Steril 2014).
- Keeps sperm counts while raising testosterone (Wiehle et al., Fertil Steril 2014).
- Across clomiphene and enclomiphene trials, total testosterone rose by about 274 ng/dL against placebo, with high variation between studies (Hohl et al., Arch Endocrinol Metab 2025).
The trial result is with the studied enclomiphene citrate at its studied dose, averaged over men. Compounded enclomiphene was not studied in these trials, and purity and dose vary between pharmacies.
What this does not say
- Sperm preservation in the 2014 trial is a laboratory outcome, not a proven pregnancy rate.
- The 2014 trial is a single phase II study.
- The long-term safety of the drug is not established.
The research
behind it.
Enclomiphene has been shown to increase testosterone, LH and FSH in men with hypogonadism, making it a valid option for those who want testosterone support while preserving their own production.
Men choosing enclomiphene often prioritize fertility preservation or the option to stop therapy later without the prolonged recovery that follows external testosterone. Your physician reviews your goals first.
Testosterone beyond the gym:
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Enclomiphene - Men?
Taken by mouth, once a day. The starting prescription is 1 capsule (12.5 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Enclomiphene - Men come in?
The pharmacy carries 2: 12.5 mg, 25 mg. Your physician chooses which one you get.
How much arrives in each shipment?
90 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why enclomiphene instead of testosterone?
Enclomiphene tells your body to make its own testosterone; external testosterone tells it to stop. Enclomiphene is chosen by men who want hormone support but need to keep sperm production intact, avoid testicular shrinkage, or preserve the ability to stop therapy easily. Your physician decides which fits you.
How is enclomiphene different from testosterone therapy?
Testosterone therapy replaces the hormone externally, which tells your body to stop making its own and shuts down LH and FSH. Enclomiphene stimulates those same signals, so your body keeps making testosterone while you take it. When you stop, your production doesn't need a long recovery period.
Do I need labs?
Yes. Your physician checks testosterone, LH, FSH and estradiol after your first 4–6 weeks, and then periodically to confirm your dose is working and staying safe. If fertility is your goal, semen parameters may be checked too.
What if I want to stop?
Stopping enclomiphene is simpler than stopping external testosterone because your own production never shut down. Your physician may taper the dose; testosterone levels typically return to your baseline within days or a few weeks.
Can I take it with other medications?
Tell your physician about every medication, especially estrogen blockers, tamoxifen, other SERMs, or any hormone treatments. Some combinations need dose adjustments or closer monitoring.
Enclomiphene educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Capsule
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
9 capsules per month
Starting at $63/mo
Capsule
Anastrozole Capsules
Anastrozole, an aromatase inhibitor used in men to control estrogen levels during testosterone therapy. Prescribed and dosed by a licensed physician.
9 capsules per month
Starting at $63/mo
Tablet
Anastrozole Tablets
FDA-approved anastrozole tablets, an aromatase inhibitor used at low doses in men on testosterone therapy whose estradiol runs high. Prescribed by a licensed physician only after blood work.
5 tablets per month
Starting at $63/mo
References
- 1.Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone. BJU Int, 2016
- 2.Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother, 2016
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.