Cream
Acne Cream
Triple-action topical for acne: antibiotic (clindamycin + erythromycin) and antifungal (ketoconazole). Covers bacterial and fungal acne.
Starting at $101/mo
Anti-agingCollagenPeptide
GHK-Cu Cream
RxPrescription onlyApplied to the skin · Once a day · Anti-aging · Collagen · Peptide
Starting at $131/mo
GHK-Cu (copper peptide) cream: supports skin remodeling, collagen, and overall radiance. A prescription cream compounded by a licensed pharmacy, applied once daily.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Copper peptide supports collagen remodeling
- Improves skin firmness, elasticity, and hydration
- No irritation; use daily indefinitely
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is GHK-Cu cream?
(bioactive copper peptide moisturizer)
This daily moisturizer contains GHK-Cu, a natural tripeptide with copper that supports wound healing and skin remodeling. It improves skin firmness, elasticity, and hydration while supporting collagen synthesis. Unlike tretinoin or active exfoliants, GHK-Cu is non-irritating and designed for daily, long-term use as a foundational anti-aging treatment.
- How it is taken
- Applied to the skin
- How often
- Once a day
- Form
- Anti-aging · Collagen · Peptide
Foundational
anti-aging daily cream with no irritation or downtime
Results accumulate over 2-3 months. Use alongside active treatments (tretinoin, acids) or as standalone anti-aging therapy.
How it works,
week by week.
Week 1
Start with one or all four depending on your skin needs. All are gentle and safe to layer.
Week 2–4
Skin feels more hydrated. Subtle radiance improvements. No irritation.
Month 2–3
Fine lines appear softer. Dark circles under eyes less noticeable. Skin tone more even.
Month 3–6+
Cumulative antioxidant and peptide benefits compound. Skin appears firmer, brighter, more resilient.
What you may notice,
and when.
Improved radiance
skin brightness and clarity build over weeks
No irritation
all four are gentle enough for daily use
Firmness over time
peptides and collagen support strengthen skin
Targeted benefits
LuminEye for eyes, HydroTone for hydration, etc.
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
All four products are gentle, non-irritating, and suitable for daily use. No sun sensitivity or downtime. Safe during pregnancy after consultation. No contraindications with other treatments. Tell your physician if you have sensitivity to any ingredient (vitamin C, peptides, etc.). These are supportive skincare, not active treatments; they complement tretinoin, acids, and other prescription options. No adverse effects reported at standard doses.
The research behind
GHK-Cu.
GHK-Cu is a copper-binding peptide. Its skin evidence is laboratory, animal and gene-expression work, reviewed by its main researchers. We did not find a controlled human trial of the topical cream.
- Reviewlaboratory and animal
A 2018 review of GHK-Cu's regenerative actions. Its abstract describes evidence from cell, animal and gene-expression studies, and makes no claim of a controlled human skin trial.
Pickart and Margolina, Int J Mol Sci 2018;19(7):1987 - Cells and tissuecollagen and elastin up
The same review states that GHK stimulates blood vessel and nerve outgrowth and increases collagen, elastin and glycosaminoglycan synthesis. These are cell and tissue findings, not measured results in people.
Pickart and Margolina, Int J Mol Sci 2018;19(7):1987 - Human datano human trial found
We found no controlled human trial of topical GHK-Cu for skin or hair. A Russian-language clinical review exists, but we could read only its abstract.
Our search, PubMed and the 2018 review
What the studies found
- Cell and animal studies, reviewed in 2018, describe GHK-Cu increasing collagen, elastin and glycosaminoglycan synthesis; unproven in people (Pickart and Margolina, Int J Mol Sci 2018).
- The same review describes tissue-repair effects in skin and other tissues, shown in lab and animal work; no human trial is named (Pickart and Margolina, Int J Mol Sci 2018).
- No controlled human trial of topical GHK-Cu for skin or hair was found in our search, so no human benefit is claimed.
The sources do not say whether these creams are compounded. GHK-Cu at the concentrations sold has not been shown in a controlled trial to improve skin. The brightening cream also contains hydroquinone 6%, a prescription drug covered in the hydroquinone section.
What this does not say
- Brightening and collagen claims for GHK-Cu rest on laboratory and animal work; we do not claim a result in people.
- Copper peptides can irritate skin; the trials we found did not report irritation systematically.
- Any brightening effect of this cream comes mostly from its hydroquinone and niacinamide, not from GHK-Cu alone.
The research
behind it.
GHK-Cu stimulates collagen and elastin synthesis. Studies show improved skin firmness, elasticity and hydration with consistent 2-3 month use.
Non-irritating and suitable for all skin types, including sensitive skin and those using prescription actives.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use GHK-Cu Cream?
Applied to the skin, once a day, at bedtime. The starting prescription is 1 to 2 pumps each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
Can I use GHK-Cu with tretinoin?
Yes. Use tretinoin at night; GHK-Cu cream in the morning or as a base layer. They work synergistically: tretinoin accelerates cell turnover, GHK-Cu supports collagen remodeling.
Can I use all four together?
Yes. Apply in order: GHK-Cu cream + Vital C5 in morning, HydroTone as hydrating layer, LuminEye under eyes. At night, use GHK-Cu again. They layer well.
Can I use these with active treatments like tretinoin?
Yes. Use actives at night; these in morning or as base layers. They support and protect your skin while tretinoin accelerates renewal.
How long before I see results?
Immediate: improved hydration and texture. At 4-8 weeks: brightening and firmness. At 12 weeks: noticeable anti-aging benefit. Results compound.
Are these sufficient anti-aging alone?
These are maintenance and support. For significant wrinkle reduction or dark spot removal, combine with active treatments (tretinoin, hydroquinone, etc.). Alone, these prevent aging and support radiance.
GHK-Cu cream educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Cream
Acne Cream with Tretinoin
Acne treatment combining antibiotics (clindamycin/erythromycin/ketoconazole) with tretinoin for faster clearance and post-acne healing.
Starting at $101/mo
Cream
Brightening Cream
Stronger prescription cream for stubborn melasma and dark spots: hydroquinone 6% with tretinoin, hydrocortisone, kojic acid and vitamins C and E. A short course, usually up to 8 weeks.
Starting at $109/mo
Cream
Clarity Cream
Acne and post-acne formula combining azelaic acid, niacinamide, clindamycin, and tretinoin. Anti-inflammatory and cell-renewing.
Starting at $109/mo
References
- 1.Vitamin C and antioxidant stability: mechanisms and skincare delivery. Cosmet Dermatol, 2015
- 2.Peptides in moisturizers: collagen stimulation and barrier support. J Cosmet Dermatol, 2019
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.