Tablet
Armour Thyroid
Armour Thyroid, a desiccated thyroid extract used to treat hypothyroidism. Commercial formulation prescribed and dosed by a licensed physician.
30 tablets per month
Starting at $129/mo
ThyroidT3Energy
Liothyronine T3 Capsules
RxPrescription onlyTaken by mouth · Once a day · 6.5–22 mcg · Thyroid · T3 · Energy
Starting at $89/mo
Liothyronine (T3): pure, active thyroid hormone in capsule form. Works faster than T4; some people feel a difference within hours. Used alone or added to T4 therapy for energy and mood.
How many capsules per month?
MonthlyEvery 3 months
30 capsulesper month
You'll receive 30 capsules per month. $109 billed monthly. Cancel anytime.
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Pure T3, the active form your cells use directly
- Faster onset than T4, effects often noticed within hours
- Dosed precisely by your physician, twice daily
Every plan includes
- Personalized, physician-guided plan
- 30 capsules per month, monthly and 3-month
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is liothyronine (T3)?
(synthetic triiodothyronine)
Liothyronine is synthetic T3, the active thyroid hormone. T4 works by being converted to T3 in your tissues; liothyronine skips the step. You feel effects sooner, often within hours. T3 has a shorter half-life than T4, so it is dosed twice daily. Some people use it alone for hypothyroidism; others add a small dose to T4 therapy to sharpen energy and mood.
- How it is taken
- Taken by mouth
- How often
- Once a day
- Dose range
- 6.5–22 mcg
- Form
- Thyroid · T3 · Energy
Active
T3 that works within hours
T3 is potent; dosing requires careful monitoring of heart rate and TSH. Do not use if you have uncontrolled high blood pressure or active angina.
How it works,
week by week.
Day 1
A US-licensed physician reviews your thyroid symptoms (fatigue, cold intolerance, weight, mood), medical history, and medications. Discusses how thyroid hormones work and the importance of lab-guided dosing.
Week 1
Start with an initial dose (usually conservative) of your prescribed thyroid hormone, taken once daily in the morning with water on an empty stomach.
Weeks 4-6
Thyroid hormones accumulate slowly; effects build over 4-6 weeks. Energy, temperature regulation, and mood may shift gradually. Keep a symptom journal.
Week 6-8
First lab check: TSH and Free T4 (or Free T3 if on T3). Your physician adjusts dose if needed. Repeat this cycle every 6-8 weeks until TSH and symptoms align.
Beyond
Thyroid hormones work best on a stable dose. Annual labs and check-ins ensure your dose stays right as your body and needs change.
What you may notice,
and when.
More energy
fatigue lifts as thyroid levels normalize
Better sleep quality
mood and sleep rhythm often improve together
Mental clarity
brain fog clears; focus and concentration return
Body temperature
cold intolerance eases as metabolism normalizes
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Thyroid hormones regulate metabolism and affect every cell. Overdosing causes tachycardia, palpitations, anxiety, insomnia, and heat intolerance; underdosing leaves fatigue and brain fog. Thyroid hormones are not for weight loss in people with normal thyroid function. Do not use if you have uncontrolled high blood pressure, active angina, or untreated adrenal insufficiency. Tell your physician about all medications, especially beta-blockers, stimulants, and any cardiac history. Stop and seek care for rapid heartbeat, chest pain, severe shortness of breath, or signs of thyroid storm (high fever, confusion, agitation).
The research behind
liothyronine.
Liothyronine (T3) is the active thyroid hormone. Trials of T3 added to levothyroxine have been small and their results have not been consistently repeated; the long-term safety of T3 alone is unresolved.
- Combination trialNo quality-of-life gain
A 2003 JAMA randomized trial by Clyde and colleagues compared levothyroxine plus liothyronine with levothyroxine alone in 46 people for 4 months. Quality-of-life scores changed similarly in both groups, and 12 of 13 neuropsychological tests did not differ.
Clyde et al., JAMA 2003 - Early trialMood signal, not repeated
Bunevicius and colleagues (NEJM 1999) gave 33 hypothyroid patients a usual levothyroxine dose and a regimen with some T4 replaced by T3, in two five-week periods. The mood and cognition gains they reported were not reproduced by later trials.
Bunevicius et al., N Engl J Med 1999; review of later evidence (PMC10522160) - SafetyUnresolved
A 2025 meta-analysis of liothyronine patients reports that its safety remains unresolved, and notes that some patients prefer combination therapy.
Risk of Death and Adverse Effects in Patients on Liothyronine, meta-analysis (PMC12527464)
What the studies found
- Early trial reported better mood and cognition with T3 added to T4; later trials did not reproduce it (Bunevicius, NEJM 1999)
- Some patients prefer combination therapy, though no trial shows a clear advantage (ATA, Thyroid 2014)
- T3 is the active thyroid hormone and acts faster than T4; this is pharmacology, not a trial result
The combination trials used levothyroxine plus liothyronine, not liothyronine alone. Compounded T3 capsules have not been studied in their own trial.
What this does not say
- T3 gives short-lived peaks in blood levels; long-term safety and heart effects are not established.
- Benefit for mood or energy is not consistently shown.
- Any dose change needs medical monitoring.
The research
behind it.
T3 has a faster onset and shorter duration than T4. It is the active hormone; your cells use it directly without conversion. At high doses, T3 can raise heart rate and blood pressure.
Adding a small T3 dose to T4 therapy improves energy and mood in some people. Your physician monitors your heart rate and lab values closely, as excess T3 can trigger palpitations or tachycardia.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Liothyronine (T3) Capsules?
Taken by mouth, once a day, in the morning. The starting prescription is 1 capsule (6.5 mcg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Liothyronine (T3) Capsules come in?
The pharmacy carries 3: 6.5 mcg, 12 mcg, 22 mcg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why would I use T3 instead of T4?
T3 acts faster and some people feel better on it, especially if T4 alone does not lift their energy. Because T3 is potent and has a short half-life, it requires twice-daily dosing and closer monitoring. Your physician weighs the benefits against the need for frequent check-ins.
Why can't I feel my dose immediately?
Thyroid hormones accumulate in your tissues and bloodstream over weeks. The half-life of T4 is about 7 days, so it takes 4-5 half-lives (1 month) to reach steady state. Be patient; your physician will adjust if needed at your 6-8 week check.
Will thyroid hormone help me lose weight if my thyroid is normal?
No. Thyroid hormones are not weight-loss drugs. They work only in people with low thyroid function. Overdosing a person with normal thyroid function causes dangerous side effects (tachycardia, heat intolerance) without weight loss.
Can I adjust my dose myself?
No. Thyroid dosing requires lab values (TSH, Free T4, Free T3) to be safe and effective. Too much causes palpitations and anxiety; too little leaves you fatigued. Your physician adjusts by the numbers and your symptoms, never by guessing.
What if T4 alone does not work for me?
Some people need T3 added or prefer a T4/T3 combination or natural desiccated thyroid. Your physician will try adjusting the T4 dose first, then explore other formulations if needed. This takes patience and close communication.
Liothyronine educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Capsule
T3 / T4 Capsules
Combination of T3 (Liothyronine) and T4 (Thyroxine) in slow-release capsules for comprehensive thyroid hormone replacement. Prescribed and dosed by a licensed physician.
30 capsules per month
Starting at $79/mo
Capsule
Thyroxine (T4) Capsules
Thyroxine (T4) slow-release capsules for thyroid hormone replacement therapy. Prescribed and dosed by a licensed physician.
30 capsules per month
Starting at $79/mo
Injection
Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Starting at $198/mo
References
- 1.Hypothyroidism: evidence-based diagnosis and management in adults. N Engl J Med, 2017
- 2.Levothyroxine replacement in primary hypothyroidism: a clinical update. J Clin Endocrinol Metab, 2012
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.