Injection
Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Starting at $198/mo
Weight lossOral GLP-1
Semaglutide ODT
RxPrescription onlyDissolved under the tongue · Once a day · 2–12 mg · Weight loss · Oral GLP-1
Starting at $219/mo
Oral semaglutide tablet taken sublingually (under the tongue), designed to mimic the weekly injection. Early-stage evidence; absorption is lower and more variable than injected forms. Physician-guided dosing.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Mimics the weekly injection in oral form
- Sublingual (under the tongue) for better absorption
- Dosing and adjustment guided by your physician
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is Semaglutide ODT?
(orally disintegrating tablet, sublingual form)
Semaglutide ODT is a compounded tablet designed to dissolve under the tongue. It mimics the weekly GLP-1 injection but is taken by mouth. Absorption through the oral mucosa is lower and more variable than injected semaglutide; bioavailability data in humans are limited.
- How it is taken
- Dissolved under the tongue
- How often
- Once a day
- Dose range
- 2–12 mg
- Form
- Weight loss · Oral GLP-1
Early-stage
oral formulation; limited human absorption data
Sublingual semaglutide absorbs into the bloodstream via the mouth lining. Absorption is variable between people and lower than injected forms. Your physician will adjust your dose based on your response.
How it works,
week by week.
Day 1
A US-licensed physician reviews your goals, medical history, and medications. Discusses how oral GLP-1 formulations work and the limited human evidence.
Week 1
Start your first dose sublingually. Keep the tablet or liquid under your tongue as instructed. Appetite may quiet quickly or gradually; effects are unpredictable.
Weeks 2–4
Your physician checks in to assess how you feel: appetite, digestion, energy, and early weight changes. Dose may be adjusted based on your response.
Months 2–3
Weight loss builds as your body adjusts. Your physician continues to monitor and refines your dose for optimal effect.
Beyond
Maintenance dosing continues; your physician decides with you how to hold or adjust your dose over time.
What you may notice,
and when.
Weight loss
pace depends on dose absorption and individual response
Appetite reduction
may appear quickly or gradually
Energy changes
some report early fatigue as eating patterns shift
Close monitoring
frequent check-ins ensure safety given limited data
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Oral semaglutide and tirzepatide are experimental formulations with limited human data. Common effects include nausea, diarrhea, constipation, and reduced appetite, often in the first weeks as absorption settles. Absorption is variable; blood levels may be unpredictable. Do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about all medications, diabetes drugs, and any history of kidney or pancreatic disease. Stop and seek care for severe abdominal pain, signs of pancreatitis, allergic reactions, or vision changes if diabetic.
The research behind
semaglutide.
Semaglutide is a GLP-1 receptor agonist. Its evidence comes from large randomized trials in adults with obesity, nearly all with the injected 2.4 mg weekly dose.
- Weightabout 15%
STEP 1: 1,961 adults with obesity or overweight and no diabetes, 68 weeks of weekly injections plus lifestyle advice. Mean weight change was -14.9% with semaglutide and -2.4% with placebo.
STEP 1, NEJM 2021 - Two yearsabout 15%
STEP 5: 304 adults, 104 weeks of weekly 2.4 mg injections with behavioral support. Mean change was -15.2% with semaglutide and -2.6% with placebo.
STEP 5, Nature Medicine 2022 - Heart events20% fewer events
SELECT: 17,604 adults aged 45 and older with overweight or obesity and existing heart disease but no diabetes, followed about 40 months. Major cardiovascular events were 6.5% on 2.4 mg weekly and 8.0% on placebo (hazard ratio 0.80).
SELECT, NEJM 2023
What the studies found
- Lowers body weight by about 15% on average over 68 weeks, against 2.4% on placebo (STEP 1, NEJM 2021).
- Keeps the loss over 104 weeks: -15.2% on semaglutide against -2.6% on placebo (STEP 5, Nature Medicine 2022).
- Lost more weight than liraglutide 3.0 mg daily: -15.8% against -6.4% at 68 weeks (STEP 8, JAMA 2022).
- Lowers major heart events by 20% in adults with overweight and heart disease but no diabetes (SELECT, NEJM 2023).
- Lowers the risk of kidney failure or death from kidney or heart causes by 24% in type 2 diabetes with chronic kidney disease (FLOW, NEJM 2024).
Trial results are for the injected 2.4 mg weekly product at the dose studied. They are averages, not predictions for one person. Compounded versions were not studied in these trials, and no trial has tested the sublingual (dissolve-under-the-tongue) form. The oral trial OASIS 4 (NEJM 2025, doi 10.1056/NEJMoa2500969) tested a 25 mg tablet swallowed, not a sublingual one.
What this does not say
- The trials ran 68 to 104 weeks. They do not show what happens over the long term after treatment is stopped.
- Nausea, diarrhea and vomiting were the most common side effects. In SELECT, 16.6% of people on semaglutide stopped the trial drug for adverse events, against 8.2% on placebo.
- SELECT and STEP trials were funded by the manufacturer; the figures are for brand-name semaglutide in trial conditions.
The research
behind it.
Oral semaglutide (traditional tablet with permeation enhancers) exists in clinical trials; sublingual compounded forms lack large human trials. Absorption depends on mouth moisture, contact time, and individual factors.
Many users report appetite reduction and weight loss; effects may take longer to develop than injected forms and require careful dose titration. Your physician monitors response closely.
GLP-1 beyond the scale:
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Semaglutide ODT?
Dissolved under the tongue, once a day. The starting prescription is 1 tablet (2 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Semaglutide ODT come in?
The pharmacy carries 6: 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg. Your physician chooses which one you get.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
How does oral semaglutide compare to the injection?
Injected semaglutide has decades of use and higher, more reliable blood levels. Sublingual semaglutide is newer; absorption is unpredictable. Your physician may start at a higher dose to account for variable absorption and adjusts based on how you feel.
Why oral instead of injection?
Oral forms avoid needles. Be aware: absorption is unpredictable and lower than injections, so effects are less reliable. Your physician will adjust your dose frequently as you respond.
What if absorption is poor?
If you see minimal effect after 4–6 weeks at a good dose, your physician may increase the dose, try a different formulation, or recommend switching to injected GLP-1 for better reliability.
How often will I need adjustments?
Frequently at first, every 1–2 weeks in the first month, to find your effective dose. Once stable, check-ins may space out to monthly or every 2 months.
Can I switch between oral and injection?
Yes. If oral doesn't work well or you need more predictable results, your physician can switch you to injected semaglutide or tirzepatide.
Semaglutide ODT educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Injection
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Starting at $99/mo
Injection
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Starting at $198/mo
Injection
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Starting at $99/mo
References
- 1.Oral semaglutide 2.4 mg once daily with permeation enhancers: a phase 2b trial for weight loss. NEJM, 2019 (Buckley ST et al.)
- 2.Semaglutide injection (Ozempic) mechanism and GLP-1 receptor agonism. Lancet, 2021 (Wilding JPH et al.)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.