Injection
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Starting at $159/mo
Men's healthTestosterone therapy
Testosterone Blend (Cyp/Enan/Prop)
RxPrescription onlyInjected into the muscle · Once a week · 100 mg total testosterone · Men's health · Testosterone therapy
Starting at $99/mo
Three-ester blend (cypionate 100 mg/mL, enanthate 100 mg/mL, propionate 50 mg/mL) for once-weekly injection. Propionate acts quickly but can sting at the injection site; fast, intermediate and long-acting components.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- One injection weekly covers fast, intermediate and long-acting coverage
- Propionate gives rapid initial rise, longer esters provide stability
- Suitable for men who prefer the benefit of mixed-ester timing
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is a testosterone ester blend?
(TES-tos-ter-own ES-ter BLEND)
A testosterone ester blend mixes three esters with different release speeds: propionate (fast, acting in days), enanthate (intermediate, ~8 days), and cypionate (long, ~7 days). Propionate reaches your bloodstream quickly, creating a rapid rise; the longer esters provide continuity as the week passes. This mix is designed for men who want all three timing profiles in a single weekly injection. Propionate can sting more at the injection site than longer esters, which is why some men choose one long-acting ester only. Your physician helps you decide which formulation suits you.
- How it is taken
- Injected into the muscle
- How often
- Once a week
- Dose range
- 100 mg total testosterone
- Form
- Men's health · Testosterone therapy
3 esters
fast, intermediate and long-acting components in one blend
Propionate is short-acting and can cause injection-site discomfort in some men. If irritation happens, tell your physician; a single long-acting ester may be better tolerated.
How it works,
week by week.
Day 1
A US-licensed physician reviews your symptoms, testosterone level, health history, risk factors and labs (testosterone, hematocrit, PSA, estradiol, lipids), and sets your dose and formulation. Your treatment ships discreetly to your door.
Weeks 1–4
You begin your chosen formulation (injection, cream, or troche). Energy, mood, and libido often begin to shift. Your physician checks in by messaging.
Month 2
Lab work (usually testosterone level and hematocrit) is drawn. Your physician reviews your symptoms and adjusts the dose if needed. Most men reach stable levels by month 2–3.
Month 3
Full check-in. Your physician reviews all labs, how you feel, side effects and whether your dose is right. If acne or mood changes appear, they are usually managed by dose adjustment.
Ongoing
Testosterone therapy continues as long as it benefits you. Labs (testosterone, hematocrit, PSA, lipids) are checked at least every 6–12 months. Your physician adjusts the dose with you over time.
What you may notice,
and when.
Energy and focus
often the first change men report
Mood and confidence
as testosterone levels stabilize
Strength and recovery
lean muscle support and workout recovery improve
Sexual desire and function
often improve noticeably
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Testosterone is a prescription hormone for symptomatic hypogonadism in men without contraindications. Common, usually temporary side effects include acne, oily skin, hair loss (or growth on the body and face), changes in mood or libido, injection-site redness or soreness, and testicular shrinkage (reversible with gonadorelin or hCG). Testosterone increases hematocrit (red blood cell concentration), which can thicken the blood and raise clot risk; your physician monitors this with lab tests and may adjust dose or suggest blood donation if hematocrit rises too high. It can worsen sleep apnea, raise blood pressure slightly, and affect cholesterol levels. Testosterone is not prescribed with a history of prostate or breast cancer, untreated or severe sleep apnea, recent heart attack or stroke, uncontrolled high blood pressure, or abnormally high hematocrit. Testosterone therapy suppresses sperm production (reversible with gonadorelin or hCG if you want to preserve fertility). If you have a partner who could be pregnant, avoid transfer of topical testosterone by washing hands thoroughly and covering the application site. Seek care immediately for chest pain, shortness of breath, unusual leg swelling, severe headache or vision changes. Tell your physician about every medication and supplement you take.
The research behind
testosterone.
Testosterone replacement is well studied in men with diagnosed low testosterone, through large randomized trials. The evidence is strongest for gels and injections; it is weaker for troches, creams and hydrogels, which were not the forms tested in those trials.
- Heart safety7.0% vs 7.3%
TRAVERSE randomized more than 5,200 men aged 45 to 80 with symptoms and low testosterone, most with heart disease or high cardiovascular risk, to daily 1.62% gel or placebo for a mean of 33 months. Major cardiac events occurred in 7.0% on testosterone and 7.3% on placebo (hazard ratio 0.96, 95% CI 0.78 to 1.17). Atrial fibrillation was more frequent on testosterone.
TRAVERSE, NEJM 2023 - Sexual functionmoderate benefit
Testosterone Trials gave men aged 65 and older with low testosterone gel for one year, raising levels to the mid-normal range of younger men. Sexual activity, desire and erectile function improved. Vitality and walking distance did not improve, and the authors said the trial was too small to judge risks.
Snyder et al., NEJM 2016 - Blood sugar12% vs 21%
In the T4DM trial, 1,007 men with overweight or obesity in a lifestyle programme received intramuscular testosterone undecanoate or placebo for two years. At two years, 2-hour glucose of 11.1 mmol/L or higher was seen in 12% of the testosterone group and 21% of the placebo group (relative risk 0.59). This was a prevention outcome in men without a hypogonadism diagnosis, not a labelled use.
Wittert et al., Lancet Diabetes Endocrinol 2021
What the studies found
- Better sexual function in older men with low testosterone: libido and, to a lesser degree, erectile function improved (Testosterone Trials, Snyder et al., NEJM 2016).
- Walking distance improved in older men with low testosterone, though vitality did not (Testosterone Trials, Snyder et al., NEJM 2016; reviewed in Snyder et al., Endocr Rev 2018).
- Mood and depressive symptoms improved slightly, while cognition did not improve (Testosterone Trials, reviewed in Snyder et al., Endocr Rev 2018).
- Hemoglobin rose in older men with unexplained anemia: 54% of treated men gained 1.0 g/dL or more, against 15% on placebo (Roy et al., JAMA Intern Med 2017).
- Lowers blood-sugar progression in overweight or obese men with impaired glucose tolerance when combined with a lifestyle programme: 12% vs 21% reached a 2-hour glucose of 11.1 mmol/L or higher at two years (T4DM, Lancet Diabetes Endocrinol 2021).
Trial results are with the studied gel or injection at the studied dose, averages across groups, not predictions for one man. Compounded and brand products were not what these trials tested. Troches, creams and hydrogels deliver the hormone differently, so the trial numbers do not transfer directly.
What this does not say
- The Endocrine Society 2018 guideline recommends testosterone for men with symptoms and consistently low levels, aiming at mid-normal values; it does not recommend it for healthy men or for preventing disease (Bhasin et al., JCEM 2018, https://doi.org/10.1210/jc.2018-00229).
- Testosterone lowers sperm production in most men, which matters if fertility is wanted.
- Long-term outcome data are limited for most forms.
The research
behind it.
Mixed-ester testosterone formulations offer a rationale combining rapid onset from propionate and sustained levels from longer esters. Clinical use shows that some men prefer the steady rise and fall over a week, while others find single esters sufficient.
The choice among testosterone formulations—single esters, blends, or daily topical—is based on your lifestyle, needle comfort, preferred injection frequency and individual response. Your physician tailors it to you.
Testosterone beyond the gym:
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
what the trials show across body systemsSex drive, blood counts, bone, blood sugar and thinking: what the Testosterone Trials and T4DM found, and where the evidence stops.Read the researchTestosterone and the heart:
what TRAVERSE foundThe safety question most men ask first: heart events, fractures, prostate and blood counts, in the largest placebo-controlled trial of testosterone.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Testosterone Cypionate / Enanthate / Propionate - Men?
Injected into the muscle, once a week. The starting prescription is 0.4 mL (100 mg total testosterone) each time. Your physician sets your own dose and it is printed on your label.
What exactly is in it?
Testosterone Cypionate, Enanthate, Propionate.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Why would I choose a blend over a single ester?
Some men prefer the faster initial rise from propionate combined with the stability of longer esters over a week. Others find it more complex than needed and prefer a single ester. It's a matter of preference and what your body responds to. If you try it and prefer different timing, your physician can switch you.
Do I need to take gonadorelin or hCG with testosterone?
Not necessarily. Gonadorelin or hCG are used if you want to preserve sperm production and testicular size while on testosterone therapy. Without them, the testes will shrink slightly and sperm production will stop—effects that reverse if you stop testosterone. Your physician discusses your priorities.
What labs do I need on testosterone therapy?
At baseline and regularly (every 6–12 months): testosterone level, hematocrit (to check for polycythemia), PSA (to screen for prostate concerns), estradiol (some testosterone converts to estrogen), and lipids (cholesterol and triglycerides). Your physician explains what the results mean and adjusts your dose based on them.
Can I stop testosterone therapy anytime?
Yes. Testosterone therapy is not a lifetime commitment; you can pause or stop. If you stop suddenly, testosterone levels will fall over days to weeks (depending on formulation) and you may feel the original hypogonadism symptoms return. Your physician helps you taper if you choose, and many men simply stop and restart later if they need to.
Testosterone blend educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Capsule
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
9 capsules per month
Starting at $63/mo
Capsule
Anastrozole Capsules
Anastrozole, an aromatase inhibitor used in men to control estrogen levels during testosterone therapy. Prescribed and dosed by a licensed physician.
9 capsules per month
Starting at $63/mo
Tablet
Anastrozole Tablets
FDA-approved anastrozole tablets, an aromatase inhibitor used at low doses in men on testosterone therapy whose estradiol runs high. Prescribed by a licensed physician only after blood work.
5 tablets per month
Starting at $63/mo
References
- 1.Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 2018
- 2.Cardiovascular Safety of Testosterone-Replacement Therapy (TRAVERSE). N Engl J Med, 2023
- 3.Pharmacology of testosterone replacement therapy preparations. Transl Androl Urol, 2016
- 4.New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab, 2004
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.