Injection
Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Starting at $139/mo
Low-dose testosteroneWomen's health
Testosterone Cream for Women
RxPrescription onlyApplied to the skin · Once a day · 2 clicks, 2 mg · Low-dose testosterone · Women's health
Starting at $79/mo
Low-dose testosterone cream for women: 0.5–2 mg daily applied to skin, enhances sexual interest, mood, and energy. Off-label use; requires estradiol monitoring for safety.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Low dose (0.5–2 mg), tailored for women's physiology
- Enhances sexual interest, mood, and energy
- Topical application once daily, easy to adjust dose
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is low-dose testosterone cream for women?
(lo-dose tes-TOS-ter-own for WU-men)
Low-dose testosterone cream for women is testosterone in a compounded topical cream, typically 0.5–2 mg daily. Applied to skin (usually inner arm or thigh), it is absorbed over 2 hours. Used off-label, it enhances sexual interest, improves mood and energy, and supports muscle tone. Because women's bodies are sensitive to testosterone, doses are far lower than for men, and estradiol levels must be monitored.
- How it is taken
- Applied to the skin
- How often
- Once a day
- Dose range
- 2 clicks, 2 mg
- Form
- Low-dose testosterone · Women's health
0.5–2 mg daily
low dose customized for women; requires estradiol monitoring
Women on testosterone must be monitored for estradiol levels (to avoid elevated conversion) and for virilization (voice deepening, facial hair), though these are rare at low doses. Benefits often appear within 2–4 weeks.
How it works,
week by week.
Day 1
US-licensed physician reviews testosterone goals, medical history, and baseline labs (testosterone, hematocrit, PSA, liver function, BP).
Week 1
Start topical testosterone (cream, hydrogel, or low-dose for women). Apply once daily to clean, dry skin. No injections or pills.
Week 4
Blood work checks testosterone level. If below target, dose is increased. If target is reached, dose is maintained.
Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, BP). Symptoms (energy, libido, mood, erectile function) reviewed.
Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted to keep testosterone in target range.
What you may notice,
and when.
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle
lean mass gains over 4–12 weeks
Lab-monitored
hematocrit, PSA, BP tracked regularly
Careful transfer prevention
wash hands, cover area, avoid skin-to-skin contact for 2 hours
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Topical testosterone (creams, hydrogels) carries the same safety considerations as all testosterone therapy: elevated hematocrit, blood pressure rise, PSA elevation, and reduced fertility during active therapy. Transfer to others (especially women and children) is possible before the application site dries. Wash hands thoroughly after application and cover the area. For women on low-dose testosterone, virilization is rare at doses <2 mg daily but must be monitored. Tell your physician about high blood pressure, blood clotting, PSA concerns, or plans to father children. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
The research behind
testosterone in women.
No testosterone product is approved for women in the US. The evidence comes from randomized trials, mostly of sexual wellbeing, and a 2019 consensus limits use to low sexual desire.
- Trial pooling36 trials, 8,480 women
Islam and colleagues pooled blinded randomized trials of testosterone in women, each at least 12 weeks long. Testosterone improved sexual desire and arousal and reduced sexual distress; the authors said effects on wellbeing, bone, cognition and long-term safety still need study.
Islam et al., Lancet Diabetes Endocrinol 2019 - ConsensusOnly for low sexual desire
The 2019 Global Consensus says the only evidence-based indication is hypoactive sexual desire disorder in women. It advises doses that keep blood testosterone near premenopausal levels, and recommends against compounded testosterone.
Davis et al., Global Consensus Position Statement on the Use of Testosterone Therapy for Women, JCEM 2019 - InjectionsCautioned against
The consensus dosing advice does not cover injections, pellets or products that give levels above premenopausal range, and it cautions against them because they tend to do exactly that.
Davis et al., Global Consensus Position Statement, JCEM 2019
What the studies found
- Improved sexual desire and arousal, and less sexual distress, than placebo across 36 randomized trials (Islam, Lancet Diabetes Endocrinol 2019)
- In women with low desire who were not using estrogen, a transdermal patch improved sexual function over 52 weeks (APHRODITE, NEJM 2008)
- Non-oral routes did not show the adverse lipid changes seen with oral testosterone (Islam, Lancet Diabetes Endocrinol 2019)
The trials used approved testosterone products at doses adjusted for women, not compounded creams or injections. Compounded testosterone cream and cypionate are not the studied products, and the consensus recommends against compounded testosterone.
What this does not say
- Trials focused on sexual wellbeing; benefit for other symptoms is not shown.
- Long-term safety, including breast and heart effects, is unclear.
- Blood levels above premenopausal range are not covered by the dosing advice.
The research
behind it.
Low-dose testosterone in women enhances libido and sexual satisfaction, improves mood, and supports lean muscle. Women metabolize testosterone differently than men due to hormonal context; lower doses are used.
Off-label testosterone for women is gaining clinical acceptance for hypoactive sexual desire disorder (HSDD) and low energy. Your physician monitors estradiol and symptoms closely.
Hormone therapy beyond hot flashes:
what the research showsBones, the heart, vaginal health and sexual desire: the trials, with their numbers and their limits.Read the researchHormone therapy and breast cancer risk:
what the trials foundEstrogen alone and with progestin, why the two differ, and how physicians weigh it.Read the research
what the research showsBones, the heart, vaginal health and sexual desire: the trials, with their numbers and their limits.Read the researchHormone therapy and breast cancer risk:
what the trials foundEstrogen alone and with progestin, why the two differ, and how physicians weigh it.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Testosterone Cream for Women (Topi-Click)?
Applied to the skin, once a day. The starting prescription is 0.5 mL (2 clicks, 2 mg) each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Inner forearm.
What strengths does Testosterone Cream for Women (Topi-Click) come in?
The pharmacy carries 3: 4 mg/mL, 2 mg/mL, 1 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Will testosterone cream make me look more masculine?
At low doses (0.5–2 mg daily), virilization (masculine features like deepened voice, facial hair) is very rare. The dose is tailored to enhance sexual interest and energy without crossing into masculinizing effects. Your physician monitors you closely and adjusts dose if any virilization signs appear.
Will topical testosterone transfer to my partner?
Transfer is possible if skin-to-skin contact occurs before the application site dries (within 2 hours). Wash your hands thoroughly after application, cover the area with clothing, and avoid skin contact. After 2 hours, the risk is minimal.
What if I forget a dose?
If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose. Do not apply extra testosterone to make up for a missed dose. Inconsistent dosing can cause fluctuations in testosterone levels.
Testosterone cream (women) educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Capsule
7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
30 capsules per month
Starting at $89/mo
Dissolving tablet
BIEST (20:80) 0.05 mg ODT
A low-dose bioidentical estrogen (20% estriol, 80% estradiol) in a tablet that dissolves in the mouth, for hot flashes, night sweats and other menopause symptoms. Prescribed and dosed by a licensed physician.
30 tablets per month
Starting at $99/mo
Dissolving tablet
BIEST (20:80) 0.1 mg ODT
A stronger dose of bioidentical estrogen (20% estriol, 80% estradiol) in a dissolving tablet, for menopause symptoms not controlled by the lower dose. Prescribed and dosed by a licensed physician.
30 tablets per month
Starting at $99/mo
References
- 1.Transdermal testosterone delivery in men: a review of pharmacokinetics and clinical outcomes. Endocrine Rev, 2018
- 2.Topical testosterone for women: low-dose efficacy and safety in sexual desire and energy. Maturitas, 2017
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.