Injection
Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Starting at $139/mo
Women's healthSexual health
Testosterone for Women (Low-Dose Cypionate)
RxPrescription onlyInjected under the skin · Once a week · 5–7.5 mg · Women's health · Sexual health
Starting at $99/mo
Low-dose testosterone 25 mg/mL in MCT oil for women with low libido or sexual dysfunction in menopause. 2.5–10 mg weekly subcutaneous, dosed by your physician per your response and labs.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Used for low libido or hypoactive sexual desire disorder (HSDD) in postmenopausal women
- Low doses, subcutaneous weekly injection, tailored to your response
- Based on the 2019 Global Consensus Position Statement on female sexual dysfunction
Every plan includes
- Personalized, physician-guided plan
- Monthly and 3-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is testosterone therapy for women?
(TES-tos-ter-own THER-a-pee)
Testosterone is a hormone naturally produced by women's adrenal glands and ovaries, in much smaller amounts than in men. In menopause, testosterone drops, and some women experience a loss of sexual desire, sexual arousal or satisfaction, collectively called hypoactive sexual desire disorder (HSDD). Low-dose testosterone therapy—typically 2.5 to 10 mg weekly by injection—can restore sexual interest and satisfaction in some women. The 2019 Global Consensus Position Statement on women's sexual health affirms testosterone as an option for postmenopausal women with HSDD. Your dose is set by your physician and adjusted based on your response and blood levels.
- How it is taken
- Injected under the skin
- How often
- Once a week
- Dose range
- 5–7.5 mg
- Form
- Women's health · Sexual health
HSDD
low sexual desire that causes distress after menopause: the one use of testosterone in women backed by the 2019 Global Consensus
Testosterone is one option among several for HSDD. Your physician discusses your symptoms, history and whether it's right for you.
How it works,
week by week.
Day 1
A US-licensed physician reviews your sexual health symptoms, menopause status, health history, risk factors and baseline labs (testosterone, estradiol, lipids, liver function). If testosterone therapy is appropriate, your dose is set and your prescription ships.
Weeks 2–4
You inject your weekly dose subcutaneously (small needle, self-injection). You may begin to notice shifts in sexual interest or desire. Your physician is available for questions.
Month 2
Lab work (testosterone level) is drawn. Your physician reviews your experience—whether libido, arousal or satisfaction have improved—and adjusts the dose if needed.
Month 3
Full check-in. Your physician reviews all labs (testosterone, estradiol, lipids), how you feel, any side effects (acne, hair, voice), and whether to continue at this dose.
Ongoing
Testosterone therapy continues as long as it helps. Labs are checked periodically (every 6–12 months). Your physician adjusts the dose as needed and discusses whether to continue.
What you may notice,
and when.
Increased sexual desire
the primary effect; often noticed within weeks
Better sexual arousal
responsiveness and satisfaction often improve
Improved sexual function
orgasm and overall sexual satisfaction may enhance
Confidence
many women report greater sexual confidence and pleasure
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Low-dose testosterone for women is prescribed for hypoactive sexual desire disorder (HSDD) in postmenopausal women without a history of hormone-sensitive cancer, cardiovascular disease, or uncontrolled high blood pressure. Common, usually mild effects include acne, increased facial or body hair (hirsutism), deepening of the voice, and increased clitoral size—changes that fully reverse when testosterone is stopped. Testosterone therapy may worsen existing sleep apnea and can slightly affect cholesterol and liver function; your physician monitors this with periodic labs. It is not prescribed during pregnancy, with a history of breast or estrogen-sensitive cancer, or untreated cardiovascular disease. Not all women tolerate or benefit from testosterone therapy; your physician helps you decide if it is right for you. Seek care immediately for chest pain, shortness of breath, leg swelling, severe headache or vision changes. Tell your physician about every medication and supplement you take.
The research behind
testosterone in women.
No testosterone product is approved for women in the US. The evidence comes from randomized trials, mostly of sexual wellbeing, and a 2019 consensus limits use to low sexual desire.
- Trial pooling36 trials, 8,480 women
Islam and colleagues pooled blinded randomized trials of testosterone in women, each at least 12 weeks long. Testosterone improved sexual desire and arousal and reduced sexual distress; the authors said effects on wellbeing, bone, cognition and long-term safety still need study.
Islam et al., Lancet Diabetes Endocrinol 2019 - ConsensusOnly for low sexual desire
The 2019 Global Consensus says the only evidence-based indication is hypoactive sexual desire disorder in women. It advises doses that keep blood testosterone near premenopausal levels, and recommends against compounded testosterone.
Davis et al., Global Consensus Position Statement on the Use of Testosterone Therapy for Women, JCEM 2019 - InjectionsCautioned against
The consensus dosing advice does not cover injections, pellets or products that give levels above premenopausal range, and it cautions against them because they tend to do exactly that.
Davis et al., Global Consensus Position Statement, JCEM 2019
What the studies found
- Improved sexual desire and arousal, and less sexual distress, than placebo across 36 randomized trials (Islam, Lancet Diabetes Endocrinol 2019)
- In women with low desire who were not using estrogen, a transdermal patch improved sexual function over 52 weeks (APHRODITE, NEJM 2008)
- Non-oral routes did not show the adverse lipid changes seen with oral testosterone (Islam, Lancet Diabetes Endocrinol 2019)
The trials used approved testosterone products at doses adjusted for women, not compounded creams or injections. Compounded testosterone cream and cypionate are not the studied products, and the consensus recommends against compounded testosterone.
What this does not say
- Trials focused on sexual wellbeing; benefit for other symptoms is not shown.
- Long-term safety, including breast and heart effects, is unclear.
- Blood levels above premenopausal range are not covered by the dosing advice.
The research
behind it.
The 2019 Global Consensus Position Statement on testosterone therapy for women identifies testosterone as an effective option for hypoactive sexual desire disorder in postmenopausal women without contraindications, with baseline and periodic labs to monitor safety.
Low-dose testosterone in postmenopausal women improves sexual desire, arousal and satisfaction, with more acne and hair growth than placebo but no serious adverse events in randomized trials. Safety monitoring includes periodic testosterone levels, lipids, and screening for androgenizing side effects.
Hormone therapy beyond hot flashes:
what the research showsBones, the heart, vaginal health and sexual desire: the trials, with their numbers and their limits.Read the researchHormone therapy and breast cancer risk:
what the trials foundEstrogen alone and with progestin, why the two differ, and how physicians weigh it.Read the research
what the research showsBones, the heart, vaginal health and sexual desire: the trials, with their numbers and their limits.Read the researchHormone therapy and breast cancer risk:
what the trials foundEstrogen alone and with progestin, why the two differ, and how physicians weigh it.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Testosterone Cypionate - Women?
Injected under the skin, once a week. The starting prescription is 0.1 mL (5 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Testosterone Cypionate - Women come in?
The pharmacy carries 2: 50 mg/mL, 25 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Is testosterone therapy safe for women?
For most postmenopausal women without a history of hormone-sensitive cancer or cardiovascular disease, low-dose testosterone has a favorable safety profile at standard doses. Common effects include mild acne, increased facial or body hair, or deepening of the voice—effects that reverse when testosterone is stopped. Your physician reviews your personal risk factors before prescribing.
Will testosterone make me "too masculine"?
No. Low-dose testosterone is tailored to postmenopausal hormone levels and does not cause masculinization. Some women notice increased facial or body hair or a slight deepening of the voice, which are reversible if you stop. Your physician monitors these effects with you.
How long until I feel a difference?
Some women notice changes in sexual interest or arousal within 2–4 weeks; others take longer. It's individual. Your physician adjusts your dose based on your response and blood testosterone level, and can increase it gradually if needed.
Can I stop testosterone therapy anytime?
Yes. Testosterone therapy is not a lifetime commitment. If you stop, testosterone levels fall within days to weeks and any masculinizing effects (hair, voice) fully reverse. Your physician can help you taper gradually if you choose.
Testosterone for women educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
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Dissolving tablet
BIEST (20:80) 0.05 mg ODT
A low-dose bioidentical estrogen (20% estriol, 80% estradiol) in a tablet that dissolves in the mouth, for hot flashes, night sweats and other menopause symptoms. Prescribed and dosed by a licensed physician.
30 tablets per month
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Dissolving tablet
BIEST (20:80) 0.1 mg ODT
A stronger dose of bioidentical estrogen (20% estriol, 80% estradiol) in a dissolving tablet, for menopause symptoms not controlled by the lower dose. Prescribed and dosed by a licensed physician.
30 tablets per month
Starting at $99/mo
References
- 1.Global Consensus Position Statement on the Use of Testosterone Therapy for Women. J Clin Endocrinol Metab, 2019
- 2.Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data. Lancet Diabetes Endocrinol, 2019
- 3.ISSWSH Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women. J Sex Med, 2021
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.