Injection
Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Starting at $198/mo
Weight lossGLP-1/GIPOral
Tirzepatide ODT
RxPrescription onlyDissolved under the tongue · Once a day · 3–12 mg · Weight loss · GLP-1/GIP · Oral
Starting at $289/mo
Oral tirzepatide tablet taken sublingually, formulated to mimic the weekly GLP-1/GIP injection. Early-stage evidence; absorption is lower and variable. Physician-supervised dosing.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Dual GLP-1/GIP in oral form
- Sublingual for enhanced absorption
- Dose adjusted by your physician
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is Tirzepatide ODT?
(orally disintegrating tablet, dual GLP-1/GIP)
Tirzepatide ODT is a compounded tablet that dissolves under the tongue to deliver the dual hormone-mimicking effect of GLP-1 and GIP. Oral tirzepatide has lower and more variable absorption than injected forms.
- How it is taken
- Dissolved under the tongue
- How often
- Once a day
- Dose range
- 3–12 mg
- Form
- Weight loss · GLP-1/GIP · Oral
Early-stage
oral dual agonist; limited human data
Sublingual tirzepatide absorbs via the oral mucosa. Bioavailability is lower and more variable than injections. Your physician starts conservatively and increases based on your tolerance and response.
How it works,
week by week.
Day 1
A US-licensed physician reviews your goals, medical history, and medications. Discusses how oral GLP-1 formulations work and the limited human evidence.
Week 1
Start your first dose sublingually. Keep the tablet or liquid under your tongue as instructed. Appetite may quiet quickly or gradually; effects are unpredictable.
Weeks 2–4
Your physician checks in to assess how you feel: appetite, digestion, energy, and early weight changes. Dose may be adjusted based on your response.
Months 2–3
Weight loss builds as your body adjusts. Your physician continues to monitor and refines your dose for optimal effect.
Beyond
Maintenance dosing continues; your physician decides with you how to hold or adjust your dose over time.
What you may notice,
and when.
Weight loss
pace depends on dose absorption and individual response
Appetite reduction
may appear quickly or gradually
Energy changes
some report early fatigue as eating patterns shift
Close monitoring
frequent check-ins ensure safety given limited data
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Oral semaglutide and tirzepatide are experimental formulations with limited human data. Common effects include nausea, diarrhea, constipation, and reduced appetite, often in the first weeks as absorption settles. Absorption is variable; blood levels may be unpredictable. Do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about all medications, diabetes drugs, and any history of kidney or pancreatic disease. Stop and seek care for severe abdominal pain, signs of pancreatitis, allergic reactions, or vision changes if diabetic.
The research behind
tirzepatide.
Tirzepatide acts on two gut hormone receptors, GLP-1 and GIP. Its evidence is large randomized trials in adults with obesity, all with the injected form.
- Weightabout 21%
SURMOUNT-1: 2,539 adults with obesity, or overweight with a weight-related condition, 72 weeks of weekly injections at 5, 10 or 15 mg. At 15 mg the mean loss was 20.9% (intention to treat), against 3.1% on placebo.
SURMOUNT-1, NEJM 2022 - Head to head20.2% vs 13.7%
SURMOUNT-5: 751 adults without diabetes, open label, 72 weeks. Maximum tolerated tirzepatide (10 or 15 mg) lost 20.2% on average; maximum tolerated semaglutide (1.7 or 2.4 mg) lost 13.7%.
SURMOUNT-5, NEJM 2025 - Large losses57% lost 20% or more
SURMOUNT-1 at 15 mg: 57% of people reached a loss of at least 20% of body weight, against 3% on placebo. The average hides a wide spread between people.
SURMOUNT-1, NEJM 2022
What the studies found
- Average weight loss of 20.9% at 72 weeks on the 15 mg dose, against 3.1% on placebo (SURMOUNT-1, NEJM 2022).
- Lost more weight than semaglutide in a head-to-head trial: -20.2% against -13.7% (SURMOUNT-5, NEJM 2025).
- Reduced apnea-hypopnea events per hour by 20 to 24 more than placebo over 52 weeks in adults with obesity and sleep apnea (SURMOUNT-OSA, NEJM 2024).
- Improved all prespecified cardiometabolic measures alongside weight loss (SURMOUNT-1, NEJM 2022).
- Kept most of the weight loss while continued: 89.5% kept at least 80% of their loss, against 16.6% on placebo (SURMOUNT-4, JAMA 2024).
Trial results are for the injected tirzepatide at the doses studied. They are averages, not predictions for one person. No trial has tested the sublingual (dissolve-under-the-tongue) form or the compounded blends.
What this does not say
- SURMOUNT-5 was open label and run by the manufacturer of tirzepatide, so the head-to-head result needs an independent check.
- The trials ran 52 to 72 weeks. Effects after stopping were not part of them, though SURMOUNT-4 shows regain after withdrawal.
- Between 4.3% and 7.1% of people on tirzepatide stopped for adverse events in SURMOUNT-1, against 2.6% on placebo.
The research
behind it.
Injected tirzepatide (the brand-name product Zepbound) produces the largest weight loss in clinical trials. Oral tirzepatide is experimental; human absorption data are very limited.
Expected effects include appetite reduction and improved metabolic markers, but onset may be slower and less predictable than injection. Your physician monitors closely.
GLP-1 beyond the scale:
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Tirzepatide ODT?
Dissolved under the tongue, once a day. The starting prescription is 1 tablet (3 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Tirzepatide ODT come in?
The pharmacy carries 8: 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 10 mg, 12 mg. Your physician chooses which one you get.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
How does oral tirzepatide compare to the shot?
Injected tirzepatide has proven efficacy and predictable blood levels. Oral tirzepatide is newer and less studied. Your physician may prescribe a higher initial dose to account for variable absorption.
Why oral instead of injection?
Oral forms avoid needles. Be aware: absorption is unpredictable and lower than injections, so effects are less reliable. Your physician will adjust your dose frequently as you respond.
What if absorption is poor?
If you see minimal effect after 4–6 weeks at a good dose, your physician may increase the dose, try a different formulation, or recommend switching to injected GLP-1 for better reliability.
How often will I need adjustments?
Frequently at first, every 1–2 weeks in the first month, to find your effective dose. Once stable, check-ins may space out to monthly or every 2 months.
Can I switch between oral and injection?
Yes. If oral doesn't work well or you need more predictable results, your physician can switch you to injected semaglutide or tirzepatide.
Tirzepatide ODT educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
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A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
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Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
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Injection
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Starting at $99/mo
References
- 1.Oral semaglutide 2.4 mg once daily with permeation enhancers: a phase 2b trial for weight loss. NEJM, 2019 (Buckley ST et al.)
- 2.Semaglutide injection (Ozempic) mechanism and GLP-1 receptor agonism. Lancet, 2021 (Wilding JPH et al.)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.