Foam
Finasteride / Minoxidil 0.25 mg / 5 mg Foam
A once-daily topical foam that combines finasteride and 5% minoxidil to slow hair loss and support regrowth; the usual starting point. Prescribed by a licensed physician.
Starting at $89/mo
Hair lossTopicalMulti-ingredient
Hair Growth Solution 5-in-1
RxPrescription onlyApplied to the scalp · Once a day · Hair loss · Topical · Multi-ingredient
Starting at $129/mo
Five-ingredient topical solution: finasteride, minoxidil, tretinoin, caffeine and azelaic acid for comprehensive hair-loss and scalp-health support.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Multiple mechanisms: DHT block, growth stimulation, scalp health
- Tretinoin enhances minoxidil activation; caffeine stimulates follicles
- One topical application daily to thinning areas
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is the 5-in-1 hair-growth solution?
(comprehensive topical cocktail)
This solution layers five ingredients: finasteride blocks DHT, minoxidil extends growth phase, tretinoin increases minoxidil activation, caffeine stimulates follicles, and azelaic acid supports scalp health and reduces inflammation. The combination targets multiple pathways, making it a comprehensive choice for aggressive hair loss or plateau response to single agents.
- How it is taken
- Applied to the scalp
- How often
- Once a day
- Form
- Hair loss · Topical · Multi-ingredient
Five
complementary mechanisms in one topical application
The 5-in-1 formulation is prescribed off-label based on the evidence for individual ingredients and clinical synergy reasoning. Scalp irritation is more likely with this potent combination.
How it works,
week by week.
Week 1
Apply to clean, dry scalp using the provided applicator. Many people start with once daily. Your physician monitors for irritation.
Week 2–4
Scalp may shed slightly as the hair cycle resets. Do not be alarmed; this is normal and temporary.
Month 1–3
Hair loss slows noticeably. New hairs begin to grow. Irritation typically subsides.
Month 3–6+
Results become visible. Your physician may increase frequency or add systemic agents if needed. Maintenance is ongoing.
What you may notice,
and when.
Minimal systemic effects
topical delivery keeps side effects local
Hair regrowth
new hairs visible by month 2-3
Scalp irritation possible
usually mild; subsides with continued use
Consistent application
daily use essential for results
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Topical finasteride, dutasteride, minoxidil, tretinoin and related ingredients are applied to the scalp and minimally absorbed systemically. Local side effects include irritation, itching, contact dermatitis, and occasional hair shedding at initiation (normal hair-cycle reset). Tretinoin increases sun sensitivity, so daily sunscreen is recommended. Do not apply to broken skin or use if pregnant or breastfeeding. Wash hands after application unless treating hands. Tell your physician about any allergies to propylene glycol or other solution components, or history of sensitive scalp. Stop and seek care for severe redness, blistering, or signs of allergic reaction.
The research behind
the topical hair combinations.
Each product combines drugs applied to the scalp: finasteride, dutasteride, minoxidil, latanoprost or tretinoin. Trials exist for most of these drugs on their own, mostly small. We did not find a trial of any of these exact combinations.
- Topical finasteride20.2 vs 6.7 hairs
Phase III trial of a topical finasteride spray in 458 men over 24 weeks. Hair count in the 1 cm² target area rose 20.2 hairs with the spray and 6.7 with placebo (P<0.001), numerically similar to oral finasteride at 21.1 hairs. This is a spray, not the foam or solution sold here.
Piraccini et al., J Eur Acad Dermatol Venereol 2022;36(2):286-94 - Minoxidil 5%superior to 2% at 48 weeks
Randomized trial in men with androgenetic alopecia. At 48 weeks the 5% minoxidil solution was significantly superior to 2% solution and to placebo for change in nonvellus hair count, and the response came earlier. It caused more pruritus and local irritation.
Olsen et al., J Am Acad Dermatol 2002 - Latanoprost16 men
Pilot trial of latanoprost 0.1% on one scalp site against placebo on another site in the same men, for 24 weeks. Hair density rose versus baseline and versus the placebo site (P<0.001 and P=0.0004). Sixteen men with mild loss is too few to size the effect.
Blume-Peytavi et al., J Am Acad Dermatol 2012;66(5):794-800
What the studies found
- Topical finasteride spray gave 20.2 hairs in a 1 cm² target area vs 6.7 for placebo at 24 weeks, similar to oral finasteride (Piraccini et al., J Eur Acad Dermatol Venereol 2022).
- 5% minoxidil solution gave more regrowth than 2% solution at 48 weeks in men (Olsen et al., J Am Acad Dermatol 2002).
- Latanoprost 0.1% increased scalp hair density over 24 weeks, in a 16-man pilot (Blume-Peytavi et al., J Am Acad Dermatol 2012).
Trial results are for each drug on its own, at the strength studied, and are averages across people. The combinations here are not the products tested; no trial of the combined foam or solution was found. Compounded versions were not studied.
What this does not say
- We found no trial of these exact combinations; the evidence is for each ingredient alone.
- Tretinoin is included as a way to help other drugs penetrate the scalp; we did not find a human trial showing that effect, so we do not claim it.
- Caffeine in the 5-in-1 solution has weak evidence for hair growth in the sources we read.
- Scalp irritation and itching are the most common complaints with topical forms.
The research
behind it.
Tretinoin enhances minoxidil activation; caffeine has shown modest follicle-stimulating effects; azelaic acid combats scalp inflammation. Finasteride and minoxidil are separately proven.
Scalp irritation, redness, or peeling can occur, especially in the first weeks. Your physician advises gradual introduction (three times weekly initially, increasing to daily) and monitoring for sensitivity.
Hair loss medicines:
what the trials showFinasteride, dutasteride and minoxidil: the numbers, the time course and what the trials do not cover.Read the researchFinasteride side effects:
what the data sayTrial rates, the nocebo question, persistence after stopping, and who should not take it.Read the research
what the trials showFinasteride, dutasteride and minoxidil: the numbers, the time course and what the trials do not cover.Read the researchFinasteride side effects:
what the data sayTrial rates, the nocebo question, persistence after stopping, and who should not take it.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Hair Growth Solution (Caffeine / Finasteride / Latanoprost / Minoxidil / Tretinoin)?
Applied to the scalp, once a day, at bedtime. The starting prescription is 1 mL each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Thinning areas of the scalp.
What exactly is in it?
Caffeine 0.1%, Finasteride 0.1%, Latanoprost 0.01%, Minoxidil 5%, Tretinoin 0.01%.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
Is the 5-in-1 solution stronger and faster than simpler combinations?
Potentially, but irritation risk is higher. Your physician may start you on finasteride / minoxidil alone and add the 5-in-1 if response plateaus. Some people tolerate the full cocktail from day one; others need a gentler ramp-up.
Why apply to dry scalp only?
Water and moisture dilute the solution, reducing its effectiveness and increasing irritation. Dry scalp ensures full-strength contact and optimal absorption.
Can I use other topical products on my scalp while using this?
Limit concurrent products. Regular shampoo is fine, but avoid other medicated scalp treatments, oils, or leave-in conditioners without your physician's approval, as they may interact.
How long before I see results?
Hair loss typically slows within 4-8 weeks. New growth becomes visible around month 2-3. Peak results occur at 6-12 months. Patience is essential.
5-in-1 hair-growth solution educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Foam
Finasteride / Minoxidil 0.25 mg / 12 mg Foam
A once-daily topical foam with finasteride and a higher 12% minoxidil for more advanced thinning or when 5% has plateaued. Prescribed by a licensed physician.
Starting at $89/mo
Foam
Finasteride / Minoxidil / Tretinoin Foam, 30 mL
Finasteride and minoxidil with tretinoin, which helps minoxidil penetrate the scalp, in a one-month foam. Prescribed by a licensed physician.
Starting at $99/mo
Capsule
Biotin / Minoxidil Capsules
Oral biotin and minoxidil to support hair growth and scalp circulation. Daily capsules for hair regrowth.
30 capsules per month
Starting at $89/mo
References
- 1.Topical minoxidil and finasteride in androgenetic alopecia: efficacy and safety. J Clin Aesthet Dermatol, 2019
- 2.Tretinoin enhancement of minoxidil response in female pattern hair loss: a systematic review. Dermatol Ther, 2020
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.