Injection
NAD+
Supports cellular energy, focus and healthy aging by restoring the NAD+ levels that decline with age, for a fraction of the cost of IV infusions.
Starting at $159/mo
MitochondrialCognitionRedox
Methylene Blue Capsules
RxPrescription onlyTaken by mouth · Once a day · 25–50 mg · Mitochondrial · Cognition · Redox
Starting at $139/mo
Methylene blue: a redox-active dye studied for mitochondrial function, cognitive support, and mild antidepressant effects. Crosses the blood-brain barrier. Causes blue urine; important precautions with certain medications.
How many capsules per month?
MonthlyEvery 3 months
30 capsulesper month
You'll receive 30 capsules per month. $159 billed monthly. Cancel anytime.
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Supports mitochondrial electron transport and ATP production
- Crosses blood-brain barrier; studied for cognitive aging
- Emerging evidence for mood and energy support
Every plan includes
- Personalized, physician-guided plan
- 30 capsules per month, monthly and 3-month
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is methylene blue?
(methylene blue, a redox-active dye)
Methylene blue is a redox-active molecule that accepts and donates electrons in cellular energy pathways. It can penetrate mitochondria and the blood-brain barrier, making it unique among antioxidants. Low-dose methylene blue is studied for supporting mitochondrial function, slowing cognitive aging, and potentially improving mood. A striking side effect: urine turns bright blue or blue-green for 24-48 hours after dosing.
- How it is taken
- Taken by mouth
- How often
- Once a day
- Dose range
- 25–50 mg
- Form
- Mitochondrial · Cognition · Redox
Emerging
mitochondrial support with cognitive and mood applications
Methylene blue is not FDA-approved for any indication but is prescribed off-label. Doses range 5-20 mg daily. Do not use with SSRIs or MAOIs (serotonin syndrome risk).
How it works,
week by week.
Day 1
Your physician reviews your energy, cognition, mood, medications, and health history. Discusses how glutathione or methylene blue support mitochondrial and antioxidant systems.
Week 1
Start with your prescribed dose of glutathione or methylene blue capsules. Take with food to improve tolerance. Expect blue urine if taking methylene blue.
Weeks 2-4
Some people notice improved energy, mood, or mental clarity. Others see no immediate change. Cellular repairs take time; be patient.
Month 2
Your physician checks in on energy, mood, cognition, and any side effects. Discuss timing, dose, or whether to continue or adjust.
Beyond
Cellular support compounds work best on a consistent schedule. Your physician reassesses every 3-6 months based on your response and evolving research.
What you may notice,
and when.
Improved energy
especially with repeated dosing over weeks
Clearer thinking
mental fog may lift gradually
Mood support
emerging evidence in depression and anxiety
Cellular protection
antioxidant and mitochondrial support
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Glutathione and methylene blue are generally well tolerated at recommended doses. Glutathione: no established upper limit; side effects are rare. Methylene blue: at therapeutic doses (5-20 mg daily) is safe, but do not combine with SSRIs, MAOIs, or tricyclic antidepressants due to serotonin syndrome risk. Tell your physician about all medications, especially psychiatric drugs. Methylene blue may reduce the efficacy of some antibiotic or chemotherapy drugs; discuss with your physician if on cancer treatment. Methylene blue can reduce oxygen saturation slightly; avoid in people with severe anemia or respiratory disease. Stop and seek care for signs of serotonin syndrome (rapid heart rate, confusion, muscle rigidity, hyperthermia) if using methylene blue with psychiatric medications.
The research behind
methylene blue.
An old dye with approved medical uses at intravenous doses. The oral capsules sold here have only small trials, mostly of brain activity in healthy adults and of short-term effects.
- Healthy adults26 adults
In a randomized, double-blind, placebo-controlled trial of 26 adults aged 22 to 62, one 280 mg oral dose (about 4 mg/kg) changed brain activity during attention and memory tasks and gave about 7% more correct answers on memory retrieval.
Rodriguez et al., Radiology 2016 - Dementiano clear benefit
Summaries of the large dementia trials report no clear overall benefit. Blinding is hard because the drug turns urine blue, so trials have used low-dose active placebos.
Alzheimer's Drug Discovery Foundation, methylene blue cognitive vitality report - Safetyserotonin risk
Low doses are linked to stomach and urinary effects. Higher doses can cause anemia and serotonin toxicity, and it should not be combined with serotonergic drugs.
Alzheimer's Drug Discovery Foundation, methylene blue cognitive vitality report
What the studies found
- Better memory retrieval: about 7% more correct answers than placebo after one 280 mg oral dose in 26 healthy adults (Rodriguez et al., Radiology 2016).
- Better retention of fear extinction one month later in 42 adults with claustrophobia, after a 260 mg dose given after training (Telch et al., Am J Psychiatry 2014). The benefit was in people who had lowered their fear during training; it may have worsened fear in the others.
- Fewer cases of postoperative delirium in older surgical patients: 7.3% against 24.2% with 2 mg/kg intravenous methylene blue (Deng et al., J Clin Anesth 2021, open-label randomized trial of 248 patients). This is an intravenous use, not capsules.
- No clear benefit for dementia in the large trials (Alzheimer's Drug Discovery Foundation summary).
The trial gave one oral 280 mg dose in healthy adults, and its outcomes were brain imaging and short tasks. The capsules sold here are 25 and 50 mg, a lower dose than the trial's.
What this does not say
- No large trial has shown a clear cognitive benefit in people with dementia.
- The healthy-adult study measured brain imaging and short tasks, not lasting cognitive change.
- Serotonergic medicines are a real interaction risk.
The research
behind it.
Methylene blue enhances mitochondrial complex I and complex III function, supporting ATP production. In animal models and small human studies, it shows neuroprotective and antidepressant-like effects.
Human clinical trials are limited and early-stage. Some small studies suggest cognitive benefits in older adults and mood improvement in depression. Your physician monitors your response carefully.
NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Methylene Blue Capsules?
Taken by mouth, once a day. The starting prescription is 1 capsule (25 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Methylene Blue Capsules come in?
The pharmacy carries 2: 25 mg, 50 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why does methylene blue turn my urine blue?
Methylene blue is a dye; your kidneys filter it, coloring urine blue or blue-green for 24-48 hours after a dose. This is harmless and expected. You may also notice blue staining of the mouth or tongue.
When will I feel better?
Energy and mood changes can take 2-4 weeks with consistent dosing. Cognitive benefits may take months to notice. Some people respond quickly; others need sustained use. Keep a symptom log.
Can I combine glutathione and methylene blue?
These are separate compounds with different mechanisms. Some physicians use both; others prefer one. Discuss your health goals and medication history with your physician to decide the best approach.
Are there interactions with my other medications?
Methylene blue has significant interactions with psychiatric medications (SSRIs, MAOIs, tricyclics) due to serotonin syndrome risk. Tell your physician about every medication you take.
Is this supported by clinical evidence?
Glutathione and methylene blue show promise in early-stage and animal studies. Human clinical trials are limited. Your physician uses these based on mechanistic reasoning and emerging evidence, not established clinical practice.
Methylene blue educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Injection
Glutathione Injection
A master antioxidant that supports your body's natural detox pathways, skin clarity and recovery. Prescribed and dosed by a licensed clinician.
Starting at $99/mo
Capsule
Glutathione Capsules
Oral Glutathione for antioxidant support, cellular health, and longevity. A master antioxidant that supports detoxification and cellular function.
30 capsules per month
Starting at $99/mo
Injection
SS-31
Elamipretide, a mitochondrial-targeting peptide studied for cellular energy and muscle function. Investigated for fatigue and age-related muscle decline.
Starting at $209/mo
References
- 1.Glutathione: a master antioxidant and cellular regulator. J Nutr Biochem, 2007
- 2.Methylene blue as a mitochondrial and neuroprotective agent. Redox Biol, 2017
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.