Capsule
CoQ10 Capsules
Coenzyme Q10 for cellular energy production, antioxidant support, and cardiovascular health. Often recommended for those on statin therapy.
30 capsules per month
Starting at $109/mo
Bone healthCardiovascularCalcium
Vitamin D3 + K2 Capsules
RxPrescription onlyTaken by mouth · Twice a week · Bone health · Cardiovascular · Calcium
Starting at $53/mo
Vitamin D3 and K2 together: D3 increases calcium absorption, K2 directs it to bone instead of arteries. Synergistic for bone strength and arterial health. Oral capsule, daily.
How many capsules per month?
MonthlyEvery 3 months
9 capsulesper month
You'll receive 9 capsules per month. $69 billed monthly. Cancel anytime.
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- D3 enhances calcium absorption; K2 activates bone proteins
- Supports bone density while protecting arterial health
- Synergistic: each improves how the other works
Every plan includes
- Personalized, physician-guided plan
- 9 capsules per month, monthly and 3-month
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is vitamin D3 + K2?
(D3 and phylloquinone or menaquinone)
D3 increases intestinal calcium absorption; K2 activates osteocalcin, a bone protein that binds calcium, and matrix Gla protein, which prevents calcium from depositing in arteries. Together, they direct dietary calcium to bone, not soft tissue. The combination is especially valuable for aging adults, women approaching menopause, and anyone with arterial calcification concerns.
- How it is taken
- Taken by mouth
- How often
- Twice a week
- Form
- Bone health · Cardiovascular · Calcium
Synergistic
D3 and K2 work together for bone and vascular health
K2 comes in two forms: K2-MK7 (from fermented foods) and K2-MK4 (from animal products). Most supplement forms use K2-MK7, which has a longer half-life.
How it works,
week by week.
Day 1
Your physician reviews your diet, lifestyle, lab values (including vitamin D level), and goals. Discusses which vitamins fill gaps and how to time them with meals.
Week 1
Start your daily vitamins with breakfast or as directed. Take fat-soluble vitamins (D, K, CoQ10, fish oil) with food to improve absorption.
Weeks 2-4
Most people tolerate vitamins well. Some notice subtle energy shifts or better joint comfort. Keep a symptom log.
Month 2-3
Your physician may check follow-up labs (vitamin D level, if supplementing D) to confirm optimal dosing.
Beyond
Vitamins work best on a consistent daily schedule. Annual labs and check-ins ensure your regimen matches your current needs.
What you may notice,
and when.
Better energy
especially if you were deficient
Stronger bones
D and K work synergistically over months
Reduced inflammation
fish oil and Q10 support recovery
Improved endurance
Q10 and fish oil support exercise capacity
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Vitamins D, K, CoQ10, and fish oil are generally well tolerated at recommended doses. D3 at very high doses (over 10,000 IU daily long-term) can raise serum calcium; your physician sets your dose. K2 is safe; no upper limit is established. Q10 is safe; high doses may cause mild GI upset or insomnia. Fish oil can thin blood slightly at high doses; tell your physician if you take anticoagulants or antiplatelet drugs. Fish oil may cause burping or GI upset in some people. Stop and seek care for signs of hypercalcemia (nausea, vomiting, confusion) or unusual bleeding.
The research behind
vitamin D3.
Vitamin D3 has been tested in large trials of people who were not selected for deficiency. Those trials did not show benefit for heart disease, cancer or mortality; the K2 bone evidence comes from a smaller trial.
- Heart and cancerNo benefit
In VITAL, 25,871 adults over 50 took 2,000 IU of vitamin D3 a day or placebo for a median of 5.3 years. Major cardiovascular events were 396 vs 409 (hazard ratio 0.97) and invasive cancer 793 vs 824 (hazard ratio 0.96).
Manson et al., NEJM 2019 (VITAL) - MortalityNo change in deaths
The D-Health trial gave older Australians 60,000 IU of vitamin D3 once a month or placebo for about 5 years. All-cause mortality did not differ (hazard ratio 1.04, 95% CI 0.93 to 1.18), and neither did cardiovascular mortality.
Neale et al., Lancet Diabetes Endocrinol 2022 (D-Health) - Vitamin K2 and boneLess bone loss in 3 years (K2 trial)
In 244 postmenopausal women aged 55 to 65, vitamin K2 (MK-7, 180 micrograms a day) for 3 years slowed the decline in bone density and bone strength compared with placebo. This applies to the K2 product, not to vitamin D3 alone.
Knapen et al., Osteoporos Int 2013 (MK-7 trial)
What the studies found
- In a secondary analysis of VITAL, vitamin D lowered the rate of confirmed autoimmune disease (hazard ratio 0.78, 95% CI 0.61 to 0.99; BMJ 2022)
- A bone density benefit has been shown for MK-7 vitamin K2 in postmenopausal women; not for vitamin D3 alone (Knapen, Osteoporos Int 2013)
- Vitamin D3 corrects deficiency; that is the established use (NIH Office of Dietary Supplements, Vitamin D fact sheet)
VITAL and D-Health tested vitamin D3 in people not selected for deficiency, at 2,000 IU daily and 60,000 IU monthly. The K2 trial tested MK-7 alone, not D3 with K2 combined; the combination capsules have no outcome trial of their own.
What this does not say
- Benefit is most often shown in people who are deficient; these trials were not limited to them.
- The K2 trial was a single, sponsor-linked study measuring bone density, not fractures.
- The combination of D3 and K2 has not been tested in an outcome trial.
The research
behind it.
D3 + K2 studies show better bone density and lower arterial calcification compared to D3 alone in populations deficient in both.
K2 is an emerging nutrient; clinical trials are ongoing. Your physician assesses your calcium status and vascular risk to decide if D3 + K2 is right for you.
NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I take Vitamin D3 / K2 Capsules?
Taken by mouth, twice a week. The starting prescription is 1 capsule each time. Your physician sets your own dose and it is printed on your label.
What exactly is in it?
Vitamin D3, K2.
How much arrives in each shipment?
9 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why add K2 to D3?
D3 without adequate K2 can increase calcium absorption but doesn't guarantee it goes to bone rather than arteries. K2 activates the proteins that bind calcium to bone matrix and prevent arterial stiffening. For bone and heart health together, the combination is ideal.
Can I take all these vitamins together?
Yes. D, K, CoQ10, and fish oil are safe to take together. Take them all with food to improve absorption. Separate any other medications by 2-4 hours from fish oil if you are on blood thinners.
How do I know if I am deficient?
Vitamin D deficiency is easy to test; your physician can check your serum 25-hydroxyvitamin D level. K, Q10, and omega-3 deficiencies are harder to test precisely, but dietary assessment and symptoms guide supplementation.
Are vitamins from food better than supplements?
Ideally, you get vitamins from food. But modern diets often fall short. Supplements fill gaps. A varied diet plus targeted supplements usually works best.
How long until I notice a change?
Energy shifts may appear in weeks; bone and joint benefits take months to become obvious. Be patient and consistent; improvements build gradually.
Vitamin D3 + K2 educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
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References
- 1.Vitamin D supplementation and bone density in older adults. JAMA, 2022
- 2.Omega-3 fatty acids and cardiovascular disease: epidemiology and effects. Circulation, 2019
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.